課程名稱 |
環境毒物學 ENVIRONMENTAL TOXICOLOGY |
開課學期 |
95-1 |
授課對象 |
工學院 環境工程學研究所 |
授課教師 |
馬鴻文 |
課號 |
EnvE7007 |
課程識別碼 |
541 M0180 |
班次 |
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學分 |
3 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期四6,7,8(13:20~16:20) |
上課地點 |
環工101 |
備註 |
限學士班四年級以上 總人數上限:40人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/951tox_env |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
1. Introduction to Risk Assessment
Framework and methodology of risk assessment
2. Principles of Toxicology
3. Exposure and Disposition of Toxicants
Routes of exposure, absorption, transport, distribution in the body, tissue uptake, target organs, compartmentalization, excretion, kinetics.
4. Metabolism of Toxicants
Phase I reactions; Phase II reactions: conjugation, synthesis; species differences, cross-species extrapolation, detoxication and activation.
5. Principles of Systemic Toxicology
Dose-response concepts, receptor theory
6. Chemical Carcinogenesis and Mutagenesis
Active intermediate, DNA adducts, initiation, promotion, progression, Bioassays.
7. Toxicology of Major Systems and Organs (group presentation)
Nervous, renal, and hematopoietic systems; liver and respiratory systems.
8. Toxic Effects of Specific Environmental Agents (group presentation)
Metals, pesticides, solvent and vapor; POPs, ECDs.
9. Physiologically-based Pharmacokinetic Modeling
10. Principles of Ecotoxicology
11. Hazard Identification
12. Release Assessment of Chemicals
13. Hazardous Waste and Toxics Management
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課程目標 |
Understand how a chemical might cause adverse effects on living organisms qualitatively and quantitatively. |
課程要求 |
Lecture, Presentation, Case discussion |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Kent, Chris, Basics of Toxicology, John Wiley & Sons, Inc., 1998.
Lu, Frank. C., Basic Toxicology: fundamentals, target organs and risk assessment, Taylor & Francis, 2002.
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評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Exam |
40% |
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2. |
Group presentations |
25% |
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週次 |
日期 |
單元主題 |
Week 1 |
9/21 |
Introduction |
Week 2 |
9/28 |
Introduction to risk assessment |
Week 3 |
10/05 |
Principle of toxicology |
Week 4 |
10/12 |
Exposure and disposition |
Week 5 |
10/19 |
Exposure and disposition |
Week 6 |
10/26 |
Metabolism of toxicants |
Week 7 |
11/02 |
Toxicity test and epidemiology |
Week 8 |
11/09 |
Principles of Systemic Toxicology |
Week 9 |
11/16 |
Toxicology of major systems and organs (group presentation) |
Week 10 |
11/23 |
Active intermediates |
Week 11 |
11/30 |
Mutagenesis and Carcinogenesis |
Week 12 |
12/07 |
PBPK |
Week 13 |
12/14 |
Regulatory toxicology |
Week 14 |
12/21 |
Air and indoor toxicants |
Week 15 |
12/28 |
Test |
Week 16 |
1/04 |
Water and soil toxicants |
Week 17 |
1/11 |
Case study group presentation |
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